Selected article for: "absence presence and control group"
Author: Sun, Shihui; Jiang, Yuting; Wang, Renxi; Liu, Chenfeng; Liu, Xiaoling; Song, Nianping; Guo, Yan; Guo, Renfeng; Du, Lanying; Jiang, Shibo; Li, Yan; Qiu, Zewu; Zhao, Guangyu; Zhou, Yusen
Title: Treatment of Paraquat-Induced Lung Injury With an Anti-C5a Antibody: Potential Clinical Application*
  • Document date: 2018_4_13
    • ID: 6ztwho9k_29
    Snippet: Normal human blood and plasma from paraquat patients were incubated in the presence/absence of IFX-1, and CD11b expression by granulocytes was analyzed. Paraquat-mediated up-regulation of CD11b expression by granulocytes was completely blocked by IFX-1 at 80 nM (Fig. 5A) ; the efficiency of blockade was consistent and significant when compared with that in the control group (p < 0.001) (Fig. 5B) . The results indicate that complement activation o.....
    Document: Normal human blood and plasma from paraquat patients were incubated in the presence/absence of IFX-1, and CD11b expression by granulocytes was analyzed. Paraquat-mediated up-regulation of CD11b expression by granulocytes was completely blocked by IFX-1 at 80 nM (Fig. 5A) ; the efficiency of blockade was consistent and significant when compared with that in the control group (p < 0.001) (Fig. 5B) . The results indicate that complement activation occurred in paraquat-poisoned patients and that complement inhibition by the anti-C5a antibody may be an effective strategy for limiting activation of inflammatory cells, thereby reducing associated tissue damage.

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