Selected article for: "accessory protein and activation stimulate"
Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity
  • Document date: 2016_1_11
    • ID: 42d77vxf_47
    Snippet: Similar to KSHV, HIV infection fails to stimulate activation of IRF3, endogenous levels of which are quickly reduced upon infection. Underscoring the importance for HIV to disrupt early IFN-I-mediated immunity, IRF3 degradation is independently promoted by two viral accessory proteins, viral infectivity factor (Vif) and viral protein R (Vpr). The E3s hijacked for this purpose are unknown (Fig. 3) , although Vif and Vpr recruit SCF-related compone.....
    Document: Similar to KSHV, HIV infection fails to stimulate activation of IRF3, endogenous levels of which are quickly reduced upon infection. Underscoring the importance for HIV to disrupt early IFN-I-mediated immunity, IRF3 degradation is independently promoted by two viral accessory proteins, viral infectivity factor (Vif) and viral protein R (Vpr). The E3s hijacked for this purpose are unknown (Fig. 3) , although Vif and Vpr recruit SCF-related components to degrade other antiviral proteins (Okumura et al., 2008) .

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