Title: Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains Document date: 1991_4_1
ID: 6acjgug3_21
Snippet: Prostaglandins have been demonstrated to inhibit LPS-and IFN-, y/LPS-induced TNF-a expression in murine macrophages (41) (42) (43) (44) . As astrorytes have the ability to secrete PGE2 (45) , we wished to determine if endogenous PGE production contributed to strain differences in TNF-a production. Lewis and BN astrorytes were treated with 1 kg/ml of indomethacin, which blocks PGE2 synthesis, and then 80 4.....
Document: Prostaglandins have been demonstrated to inhibit LPS-and IFN-, y/LPS-induced TNF-a expression in murine macrophages (41) (42) (43) (44) . As astrorytes have the ability to secrete PGE2 (45) , we wished to determine if endogenous PGE production contributed to strain differences in TNF-a production. Lewis and BN astrorytes were treated with 1 kg/ml of indomethacin, which blocks PGE2 synthesis, and then 80 4
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