Author: Rocio Bravo Jeria; Maria X Rojas Reyes; Juan V Franco; Maria P Acuna; Luz A Torres Lopez; Gabriel rada Rada
Title: Chloroquine and hydroxychloroquine for the treatment of COVID-19: A living systematic review protocol Document date: 2020_4_8
ID: fckn8ld4_3
Snippet: Many candidate drugs have been proposed as potentially effective, but the antimalarial agents chloroquine and hydroxychloroquine have attracted more attention than any other medication [9] . Some in vitro studies have suggested they would exert antiviral properties by inhibiting ph-dependant steps of viral replication [10] , not only against SARS-COV-2, but also Chikungunya, Dengue, Zika, Influenza A H1N1 and H3N2, Coronavirus HCoV-229E, SARS-CoV.....
Document: Many candidate drugs have been proposed as potentially effective, but the antimalarial agents chloroquine and hydroxychloroquine have attracted more attention than any other medication [9] . Some in vitro studies have suggested they would exert antiviral properties by inhibiting ph-dependant steps of viral replication [10] , not only against SARS-COV-2, but also Chikungunya, Dengue, Zika, Influenza A H1N1 and H3N2, Coronavirus HCoV-229E, SARS-CoV and MERS-CoV, among others [11] , [12] . Other researchers have found an anti-inflammatory and immune-stimulating effect mediated by TNF-and IL-6 that would block the cascade of events leading to acute respiratory distress syndro me [10] .
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