Predicting Mortality in Patients with Tuberculous Destroyed Lung Receiving Mechanical Ventilation

Kim, Won-Young; Kim, Mi-Hyun; Jo, Eun-Jung; Eom, Jung Seop; Mok, Jeongha; Kim, Ki Uk; Park, Hye-Kyung; Lee, Min Ki; Lee, Kwangha

In model 2, BNP was included as an additional variable in the regression model, since pulmonary hypertension is associated with poor prognosis in chronic pulmonary tuberculosis 16, 17 and BNP is a non-invasive marker of pulmonary hypertension 18, 19 (Table 3 ). In accordance with the β values in this model, the following modified TDL-Vent score was developed: (1) vasopressor use (+1 point); (2) PaO 2 /FiO 2 ratio <180 (+2 points); and (3) BNP ≥330 pg/mL (+1 point). The model had acceptable discrimination (AUC, 0.76) and calibration (Hosmer and Lemeshow chi-square, 54.66; p=0.69). For modi- fied TDL-Vent scores ranging from 0 to ≥3, 60-day mortality rates were 0%, 21%, 33%, and 57%, respectively (log-rank test, p=0.001) ( Figure 1B) . The AUC of the modified TDL-Vent score for predicting ICU mortality was 0.74 (95% CI, 0.64-0.82) (Figure 3 ). The cut-off score for predicting mortality was ≥2, with a sensitivity of 65% and a specificity of 71%. Table 4 shows the clinical outcomes of study patients, as stratified according to the TDL-Vent scores from models 1 and 2.