Author: Kim, Won-Young; Kim, Mi-Hyun; Jo, Eun-Jung; Eom, Jung Seop; Mok, Jeongha; Kim, Ki Uk; Park, Hye-Kyung; Lee, Min Ki; Lee, Kwangha
Title: Predicting Mortality in Patients with Tuberculous Destroyed Lung Receiving Mechanical Ventilation Document date: 2018_6_19
ID: 34je017c_16
Snippet: In model 2, BNP was included as an additional variable in the regression model, since pulmonary hypertension is associated with poor prognosis in chronic pulmonary tuberculosis 16, 17 and BNP is a non-invasive marker of pulmonary hypertension 18, 19 (Table 3 ). In accordance with the β values in this model, the following modified TDL-Vent score was developed: (1) vasopressor use (+1 point); (2) PaO 2 /FiO 2 ratio <180 (+2 points); and (3) BNP â‰.....
Document: In model 2, BNP was included as an additional variable in the regression model, since pulmonary hypertension is associated with poor prognosis in chronic pulmonary tuberculosis 16, 17 and BNP is a non-invasive marker of pulmonary hypertension 18, 19 (Table 3 ). In accordance with the β values in this model, the following modified TDL-Vent score was developed: (1) vasopressor use (+1 point); (2) PaO 2 /FiO 2 ratio <180 (+2 points); and (3) BNP ≥330 pg/mL (+1 point). The model had acceptable discrimination (AUC, 0.76) and calibration (Hosmer and Lemeshow chi-square, 54.66; p=0.69). For modi- fied TDL-Vent scores ranging from 0 to ≥3, 60-day mortality rates were 0%, 21%, 33%, and 57%, respectively (log-rank test, p=0.001) ( Figure 1B) . The AUC of the modified TDL-Vent score for predicting ICU mortality was 0.74 (95% CI, 0.64-0.82) (Figure 3 ). The cut-off score for predicting mortality was ≥2, with a sensitivity of 65% and a specificity of 71%. Table 4 shows the clinical outcomes of study patients, as stratified according to the TDL-Vent scores from models 1 and 2.
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