Title: Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain Document date: 1996_7_2
ID: 45x96b5d_35
Snippet: DDDm, leaving a considerable amount of the protein retained in the early compartment(s). In fact, these chimeric genes were able to complement the lethality of the SEC12 gene disruption on a multicopy plasmid. Since the NH2terminal cytoplasmic domain is the only region originating from Secl2p in the case of SDDm, these observations strongly suggest that this domain also has a signal to localize the protein......
Document: DDDm, leaving a considerable amount of the protein retained in the early compartment(s). In fact, these chimeric genes were able to complement the lethality of the SEC12 gene disruption on a multicopy plasmid. Since the NH2terminal cytoplasmic domain is the only region originating from Secl2p in the case of SDDm, these observations strongly suggest that this domain also has a signal to localize the protein.
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