Selected article for: "dipeptidyl peptidase and MERS cov"
Author: Almazán, Fernando; DeDiego, Marta L.; Sola, Isabel; Zuñiga, Sonia; Nieto-Torres, Jose L.; Marquez-Jurado, Silvia; Andrés, German; Enjuanes, Luis
Title: Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate
  • Document date: 2013_9_10
    • ID: 14yfs4pa_3
    Snippet: A functional receptor of MERS-CoV is dipeptidyl peptidase 4 (DPP-4) from both human and bat (16) . This receptor binds to a 231-residue region in the spike (S) protein of MERS-CoV (17, 18) , a domain different from the receptor-binding site of other Betacoronaviruses (18) . Infection of human airways by MERS-CoV prevents the induction of interferon-regulating factor 3 (IRF-3)mediated antiviral alpha/beta interferon (IFN-␣/␤) responses. Howeve.....
    Document: A functional receptor of MERS-CoV is dipeptidyl peptidase 4 (DPP-4) from both human and bat (16) . This receptor binds to a 231-residue region in the spike (S) protein of MERS-CoV (17, 18) , a domain different from the receptor-binding site of other Betacoronaviruses (18) . Infection of human airways by MERS-CoV prevents the induction of interferon-regulating factor 3 (IRF-3)mediated antiviral alpha/beta interferon (IFN-␣/␤) responses. However, MERS-CoV was markedly more sensitive to the antiviral state established by ectopic IFN than severe acute respiratory syndrome CoV (SARS-CoV) (14, 19, 20) .

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