Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load Document date: 2015_10_23
ID: 259cspey_41
Snippet: Host miRNAs can modulate HIV replication either directly by targeting HIV RNA, or targeting the mRNAs that encode host cell factors relevant to HIV replication. miR-217 was found induced by Tat and increased HIV-1 expression by targeting sirtuin-1 (SIRT-1) with deacetylase activity inactivating Tat function [53] . miR-198 was shown to inhibit HIV-1 gene expression and replication in monocytes, action linked to its down-regulation of cyclin T1 [54.....
Document: Host miRNAs can modulate HIV replication either directly by targeting HIV RNA, or targeting the mRNAs that encode host cell factors relevant to HIV replication. miR-217 was found induced by Tat and increased HIV-1 expression by targeting sirtuin-1 (SIRT-1) with deacetylase activity inactivating Tat function [53] . miR-198 was shown to inhibit HIV-1 gene expression and replication in monocytes, action linked to its down-regulation of cyclin T1 [54] .
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