Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load Document date: 2015_10_23
ID: 259cspey_63
Snippet: Counteracting the effect of HATs, the histone deacetylase proteins (HDAC) remove the acetyl-group from HATacetylated histones to enforce transcriptional silencing. In the HIV-1 LTR, it is thought that the LSF protein binds at position 10 to +27 of the LTR to recruit the YY1 factor which further binds HDAC-1 to silence viral transcription. Tat expression down regulates HDAC-1 to remove the transcription repression. A similar recovery from repressi.....
Document: Counteracting the effect of HATs, the histone deacetylase proteins (HDAC) remove the acetyl-group from HATacetylated histones to enforce transcriptional silencing. In the HIV-1 LTR, it is thought that the LSF protein binds at position 10 to +27 of the LTR to recruit the YY1 factor which further binds HDAC-1 to silence viral transcription. Tat expression down regulates HDAC-1 to remove the transcription repression. A similar recovery from repressive inhibition has been obtained through treatment with HDAC inhibitors (HDACIs) such as Trichostatin A (TSA), Valproic Acid (VPA), and sodium butyrate.
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