Title: Proceedings 31st Symposium ESVN-ECVN Document date: 2019_12_21
ID: 4526ne4l_437
Snippet: Diazepam (DZ) is the standard firstâ€line treatment for Status Epilepticus in dogs. Sustained epileptic activity causes a sharp decline in DZ therapeutic efficacy which worsened over 30 minutes probably due to the SEâ€associated subunitâ€specific trafficking of GABAA. Levetiracetam (LEV) is a new antiepileptic drug, whom mechanism of action is not related to GABAA receptors. Hence, the aim of this study was to evaluate the therapeutic efficacy.....
Document: Diazepam (DZ) is the standard firstâ€line treatment for Status Epilepticus in dogs. Sustained epileptic activity causes a sharp decline in DZ therapeutic efficacy which worsened over 30 minutes probably due to the SEâ€associated subunitâ€specific trafficking of GABAA. Levetiracetam (LEV) is a new antiepileptic drug, whom mechanism of action is not related to GABAA receptors. Hence, the aim of this study was to evaluate the therapeutic efficacy of LEV and compare that with DZ in dogs with SE established for ≥30 minutes (ID 817â€2017).
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