Author: TAKANO, Tomomi; YAMASHITA, Saya; MURATA-OHKUBO, Michiko; SATOH, Kumi; DOKI, Tomoyoshi; HOHDATSU, Tsutomu
Title: Prevalence of canine coronavirus (CCoV) in dog in Japan: detection of CCoV RNA and retrospective serological analysis Document date: 2015_10_11
ID: 2kg967bh_2
Snippet: Since CCoV is classified into types I (CCoV-I) and II (CCoV-II) based on differences in the spike (S) protein amino acid sequence [8] . In addition, the CCoV-I genome contains a CCoV-I-specific ORF-3 gene, and CCoV-I and -II can also be distinguished based on the presence or absence of this gene [7] . Feline coronavirus (FCoV) of the genus Alphacoronavirus is also classified into types I (FCoV-I) and II (FCoV-II), as with the CCoV [6, 10] . The S.....
Document: Since CCoV is classified into types I (CCoV-I) and II (CCoV-II) based on differences in the spike (S) protein amino acid sequence [8] . In addition, the CCoV-I genome contains a CCoV-I-specific ORF-3 gene, and CCoV-I and -II can also be distinguished based on the presence or absence of this gene [7] . Feline coronavirus (FCoV) of the genus Alphacoronavirus is also classified into types I (FCoV-I) and II (FCoV-II), as with the CCoV [6, 10] . The S protein sequence is highly homologous between CCoV-I and FCoV-I and between CCoV-II and FCoV-II [8] . The homology of the S protein amino acid sequence is about 80% between CCoV-I and FCoV-I, whereas it is about 50% between CCoV-I and CCoV-II/FCoV-II [8] . FCoV-I and FCoV-II/CCoV-II can be distinguished by neutralization tests [10] .
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