Author: Kim, Sung-Kwon; Cornberg, Markus; Wang, Xiaoting Z.; Chen, Hong D.; Selin, Liisa K.; Welsh, Raymond M.
Title: Private specificities of CD8 T cell responses control patterns of heterologous immunity Document date: 2005_2_21
ID: 55gi6gyx_9
Snippet: Analysis of individual LCMV-immune mice (day 0) revealed some small variations in the magnitude of the T cell response, but little variation in the epitope hierarchy (Fig. 1, A and B ). PV infection, as expected, induced a dramatic expansion of the strongly cross-reactive NP205-specific CD8 T cells in all of the PV-infected, LCMV-immune mice ( Fig. 1 A) . Concomitant with the expansion, there were significant reductions in the frequencies of th.....
Document: Analysis of individual LCMV-immune mice (day 0) revealed some small variations in the magnitude of the T cell response, but little variation in the epitope hierarchy (Fig. 1, A and B ). PV infection, as expected, induced a dramatic expansion of the strongly cross-reactive NP205-specific CD8 T cells in all of the PV-infected, LCMV-immune mice ( Fig. 1 A) . Concomitant with the expansion, there were significant reductions in the frequencies of the rest of the noncross-reactive LCMV-specific CD8 T cells. Analyses of these three and seven other individual LCMV-immune mice infected with PV revealed that, although the level of the NP205-specific T cell expansion widely varied (2-41-fold, mean Ï 14.5 Ï® 15, median Ï 6.9, n Ï 10) between individual mice, all of the PV-infected LCMV-immune mice unambiguously exhibited the same pattern of expansion of T cells specific to this cross-reactive epitope.
Search related documents:
Co phrase search for related documents- cell expansion and dramatic expansion: 1
- cell expansion and significant reduction: 1
- cell response and cross reactive epitope: 1, 2, 3, 4, 5, 6, 7
- cell response and PV infection: 1
- cell response and significant reduction: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cross reactive epitope and dramatic expansion: 1
- cross reactive epitope and epitope hierarchy: 1
- cross reactive epitope and lcmv immune mouse: 1, 2, 3, 4
- cross reactive epitope and PV infection: 1
- dramatic expansion and lcmv immune mouse: 1
- dramatic expansion and PV infection: 1
- epitope hierarchy and lcmv immune mouse: 1
- epitope hierarchy and PV infection: 1
- individual LCMV immune mouse and lcmv immune mouse: 1
- individual mouse and lcmv immune mouse: 1
- individual mouse and significant reduction: 1
- lcmv immune mouse and PV infection: 1, 2
Co phrase search for related documents, hyperlinks ordered by date