Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026)

Atreya, Chintamani; Glynn, Simone; Busch, Michael; Kleinman, Steve; Snyder, Edward; Rutter, Sara; AuBuchon, James; Flegel, Willy; Reeve, David; Devine, Dana; Cohn, Claudia; Custer, Brian; Goodrich, Raymond; Benjamin, Richard J.; Razatos, Anna; Cancelas, Jose; Wagner, Stephen; Maclean, Michelle; Gelderman, Monique; Cap, Andrew; Ness, Paul

Both technologies represent examples of first-generation efforts toward developing a technology that can maintain the product potency while eradicating nucleic acid-containing pathogens. If the goal is to increase the safety with a tradeoff of 10% reduction in RBC, the results provided indicate that the potency of RBCs treated with both PR products, especially riboflavin/UV light, would fall short of such goal. I believe that these results may form part of the basis for the discussion on the development of improved protocols and/or approaches to PR of WB in general and, specifically, RBCs. A nucleic acid-binding photosensitizer with flexible structure for pathogen inactivation in red blood cell suspensions-Stephen J. Wagner, PhD