Author: Yan, Xiujuan; Li, Yingxiu; Choi, Yun Ho; Wang, Chongyang; Piao, Yihua; Ye, Jing; Jiang, Jingzhi; Li, Liangchang; Xu, Huixian; Cui, Qingsong; Yan, Guanghai; Jin, Minggen
Title: Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats Document date: 2018_10_8
ID: 7ea7ur3b_33
Snippet: Alprostadil is extensively used clinically for the treatment of multiple-system diseases [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [41] [42] [43] . However, the therapeutic effect of alprostadil in ARDS remains unclear. It was reported that Alprostadil exerts its effect through protecting the pulmonary vascular endothelial cells [8] [9] [10] . However, the OA-induced ARDS model features injury to pulmonary vascular endothelial cells [29, .....
Document: Alprostadil is extensively used clinically for the treatment of multiple-system diseases [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [41] [42] [43] . However, the therapeutic effect of alprostadil in ARDS remains unclear. It was reported that Alprostadil exerts its effect through protecting the pulmonary vascular endothelial cells [8] [9] [10] . However, the OA-induced ARDS model features injury to pulmonary vascular endothelial cells [29, 30] . Thus, in the present study, the OA-induced ARDS model was used to investigate the role of Alprostadil in ARDS.
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