Author: Pickett, Brett E.; Sadat, Eva L.; Zhang, Yun; Noronha, Jyothi M.; Squires, R. Burke; Hunt, Victoria; Liu, Mengya; Kumar, Sanjeev; Zaremba, Sam; Gu, Zhiping; Zhou, Liwei; Larson, Christopher N.; Dietrich, Jonathan; Klem, Edward B.; Scheuermann, Richard H.
Title: ViPR: an open bioinformatics database and analysis resource for virology research Document date: 2011_10_17
ID: 48ym7eti_28
Snippet: Sequence feature variant types. The SFVT component of ViPR can be used to identify the characterized structural and functional regions in the DENV polyprotein that contain the substitutions found to differentiate the metadata groups. For the current use case, polyprotein position 620 was one of 37 residues that were identified as significantly differing between the two DENV-2 lineages. This position is located within a structural SF named Dengue_.....
Document: Sequence feature variant types. The SFVT component of ViPR can be used to identify the characterized structural and functional regions in the DENV polyprotein that contain the substitutions found to differentiate the metadata groups. For the current use case, polyprotein position 620 was one of 37 residues that were identified as significantly differing between the two DENV-2 lineages. This position is located within a structural SF named Dengue_Virus_2_Beta-strand_617 (8) , indicating that this region contains a b-strand protein secondary structure that begins at residue 617 of the polyprotein and continues for 8 residues ( Figure 1C) , with the Brazilian introduction corresponding to VT-1 and the Nicaraguan introduction to VT-2.
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