Author: Yan, Xiujuan; Li, Yingxiu; Choi, Yun Ho; Wang, Chongyang; Piao, Yihua; Ye, Jing; Jiang, Jingzhi; Li, Liangchang; Xu, Huixian; Cui, Qingsong; Yan, Guanghai; Jin, Minggen
Title: Protective Effect and Mechanism of Alprostadil in Acute Respiratory Distress Syndrome Induced by Oleic Acid in Rats Document date: 2018_10_8
ID: 7ea7ur3b_38
Snippet: Alprostadil has protective effects against lung injury in OAinduced ARDS. This protective effect might be related to its ability to prevent the release of pro-inflammatory mediators, suppressing the activation of MAPKs and NF-kB signaling pathways, down-regulating ACE expression, and inhibiting lung cell apoptosis. Our data thus suggest that alprostadil is a promising drug for use in the treatment of ARDS......
Document: Alprostadil has protective effects against lung injury in OAinduced ARDS. This protective effect might be related to its ability to prevent the release of pro-inflammatory mediators, suppressing the activation of MAPKs and NF-kB signaling pathways, down-regulating ACE expression, and inhibiting lung cell apoptosis. Our data thus suggest that alprostadil is a promising drug for use in the treatment of ARDS.
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