Selected article for: "gene expression and regulate gene"
Author: Lin, Ya-Hui; Chang, Kung-Yao
Title: Rational design of a synthetic mammalian riboswitch as a ligand-responsive -1 ribosomal frame-shifting stimulator
  • Document date: 2016_10_14
    • ID: 1pou702r_1
    Snippet: RNA modules capable of recognizing specific metabolites to regulate gene expression have been identified in the 5 UTR of a variety of prokaryotic genes (1) (2) (3) . Such riboswitches can control accessibility of Shine-Dalgarno (SD) sequences and intrinsic transcriptional termination hairpins to tune translation initiation and transcription termination efficiencies, respectively (1) (2) (3) . The ability to control RNA conformations by metabolite.....
    Document: RNA modules capable of recognizing specific metabolites to regulate gene expression have been identified in the 5 UTR of a variety of prokaryotic genes (1) (2) (3) . Such riboswitches can control accessibility of Shine-Dalgarno (SD) sequences and intrinsic transcriptional termination hairpins to tune translation initiation and transcription termination efficiencies, respectively (1) (2) (3) . The ability to control RNA conformations by metabolites or artificial organic molecules to regulate specific gene expressions in higher eukaryotic systems could provide new opportunities in biomedical and synthetic biological applications (4, 5) .

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