Author: Glantz-Gashai, Yitav; Meirson, Tomer; Reuveni, Eli; Samson, Abraham O
Title: Virtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance Document date: 2017_6_19
ID: 47srfqzl_56
Snippet: This study postulates an additional target for some FDAapproved drugs, which may in fact also act on Mcl-1. Some of these drugs are already undergoing clinical trials as noted earlier. As such, this study paves the way for more informed clinical trials, in vivo and in vitro studies, experimental binding assays, and so on. Importantly, if a drug is already approved by the FDA for the treatment of cancer, then the clinical use of the potential Mcl-.....
Document: This study postulates an additional target for some FDAapproved drugs, which may in fact also act on Mcl-1. Some of these drugs are already undergoing clinical trials as noted earlier. As such, this study paves the way for more informed clinical trials, in vivo and in vitro studies, experimental binding assays, and so on. Importantly, if a drug is already approved by the FDA for the treatment of cancer, then the clinical use of the potential Mcl-1 inhibitors could be very promising.
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