Author: Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann
Title: Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii Document date: 2019_8_10
ID: 0co6m9af_1
Snippet: Bats are major reservoirs for viral zoonotic pathogens. Virus infections that are acute and highly aggressive in humans can be persistent and avirulent in bats (Calisher et al., 2006) . An important contributor of virus tolerance by bats is thought to be the antiviral type I interferon (IFN-a/b) system (Dobson, 2005) . Indeed, in some bats the IFN system has peculiar features and is under strong positive selection (De La Cruz-Rivera et al., 2018;.....
Document: Bats are major reservoirs for viral zoonotic pathogens. Virus infections that are acute and highly aggressive in humans can be persistent and avirulent in bats (Calisher et al., 2006) . An important contributor of virus tolerance by bats is thought to be the antiviral type I interferon (IFN-a/b) system (Dobson, 2005) . Indeed, in some bats the IFN system has peculiar features and is under strong positive selection (De La Cruz-Rivera et al., 2018; Pavlovich et al., 2018; Yan, 2015; Zhang et al., 2013; Zhou et al., 2016) . Bats may thus possess a fortified IFN system that suppresses viruses down to levels of persistence (Dobson, 2005; Pavlovich et al., 2018; Wynne and Wang, 2013; Zhang et al., 2013) .
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