Author: Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann
Title: Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii Document date: 2019_8_10
ID: 0co6m9af_23
Snippet: CH25H is a powerful broad-spectrum inhibitor of virus entry (Liu et al., 2013; Reboldi et al., 2014) . It is not responsive to NDV infection in P. vampyrus cells (Glennon et al., 2015) . CH25H is published as being weakly IFN stimulated in human (which we could not observe in our A549 cells), rat, horse, and dog; unresponsive to IFN in sheep, pigs and bats; and actually downregulated in cattle (Shaw et al., 2017) . Thus, CH25H is a little conserv.....
Document: CH25H is a powerful broad-spectrum inhibitor of virus entry (Liu et al., 2013; Reboldi et al., 2014) . It is not responsive to NDV infection in P. vampyrus cells (Glennon et al., 2015) . CH25H is published as being weakly IFN stimulated in human (which we could not observe in our A549 cells), rat, horse, and dog; unresponsive to IFN in sheep, pigs and bats; and actually downregulated in cattle (Shaw et al., 2017) . Thus, CH25H is a little conserved (and weak) ISG that we find in humans and M. daubentonii to be a novel and strong virusresponse gene.
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