Selected article for: "broad spectrum and genome expression"
Author: Hölzer, Martin; Schoen, Andreas; Wulle, Julia; Müller, Marcel A.; Drosten, Christian; Marz, Manja; Weber, Friedemann
Title: Virus- and Interferon Alpha-Induced Transcriptomes of Cells from the Microbat Myotis daubentonii
  • Document date: 2019_8_10
    • ID: 0co6m9af_28
    Snippet: iScience 19, 647-661, September 27, 2019 655 BST2 gene, whereas Miniopterus natalensis (Yangochiroptera/Miniopteridae) seems to have just one copy ( Figure 6B and data not shown). Using our M. daubentonii RNA-seq data, we were able to detect expression of four BST2 paralogs in the genome of M. lucifugus. However, two had an identical sequence (data not shown), so we confirm three BST2 paralogs with a differing sequence in the transcriptome of M. .....
    Document: iScience 19, 647-661, September 27, 2019 655 BST2 gene, whereas Miniopterus natalensis (Yangochiroptera/Miniopteridae) seems to have just one copy ( Figure 6B and data not shown). Using our M. daubentonii RNA-seq data, we were able to detect expression of four BST2 paralogs in the genome of M. lucifugus. However, two had an identical sequence (data not shown), so we confirm three BST2 paralogs with a differing sequence in the transcriptome of M. daubentonii. Thus, Vespertilionidae microbats are unique in harboring a multitude of BST2 paralogs, since all other species (except for sheep, which have two [Varela et al., 2017] ) have only one copy. Overall, our observations are that Yangochiroptera/Vespertilionidae microbats express a high number of paralogs of Mx and unexpectedly also BST2, two ISGs with a broad antiviral spectrum. This may indicate an increased capability to directly fend off virus infections.

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