Selected article for: "causative agent and cell membrane"
Author: Welch, Matthew D.
Title: Why should cell biologists study microbial pathogens?
  • Document date: 2015_12_1
    • ID: 04xyhhmf_8
    Snippet: Advances in our understanding of how membrane-trafficking pathways contribute to repairing plasma membrane wounds (Sonnemann and Bement, 2011) have also come from the study of intracellular pathogens. A classic example is Trypanosoma cruzi, a eukaryotic parasite and the causative agent of Chagas disease, which in its chronic form can cause cardiovascular and intestinal illness. As the T. cruzi parasite contacts the plasma membrane of a host cell .....
    Document: Advances in our understanding of how membrane-trafficking pathways contribute to repairing plasma membrane wounds (Sonnemann and Bement, 2011) have also come from the study of intracellular pathogens. A classic example is Trypanosoma cruzi, a eukaryotic parasite and the causative agent of Chagas disease, which in its chronic form can cause cardiovascular and intestinal illness. As the T. cruzi parasite contacts the plasma membrane of a host cell before invasion, intracellular Ca 2+ is elevated, and cellular lysosomes are recruited to the point of contact between the parasite identifying cellular targets of pathogens led to the development of therapeutic agents to treat infection?

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