Selected article for: "bind protein and protein synthesis"
Author: Fu, Yu; Lee, Inhan; Lee, Yong Sun; Bao, Xiaoyong
Title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
  • Document date: 2015_12_31
    • ID: 0b08jyjs_12
    Snippet: In addition to tRNA halves, tRFs have also been reported to be involved in global translational inhibition in human cells. In the archaeon Haloferax volcanii a 26-nt long tRF-5 originating from tRNA Val in a stress-dependent manner was shown to directly bind to the small ribosomal subunit and reduce protein synthesis by interfering with peptidyl transferase activity [45] . A similar mechanism of translation inhibition by a tRF-5 was also observed.....
    Document: In addition to tRNA halves, tRFs have also been reported to be involved in global translational inhibition in human cells. In the archaeon Haloferax volcanii a 26-nt long tRF-5 originating from tRNA Val in a stress-dependent manner was shown to directly bind to the small ribosomal subunit and reduce protein synthesis by interfering with peptidyl transferase activity [45] . A similar mechanism of translation inhibition by a tRF-5 was also observed in human cells [46] . A 19-nt long tRF-5 derived from tRNA Gln decreased the expression of a reporter gene that did not have a sequence complementary to that of the tRF-5, suggesting that nonspecific translational repression is mediated by this tRF-5. An interesting observation from this study was that the tRFs required a conserved "GG" dinucleotide for their activity in inhibiting translation. Because the tRF-5 series were detected in the polysome fraction, interaction of the tRF-5 with the ribosome may contribute to translation [46] .

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