Author: Khawaja, Fareed; Chemaly, Roy F.
Title: Respiratory syncytial virus in hematopoietic cell transplant recipients and patients with hematologic malignancies Document date: 2019_7_23
ID: 4fx18mlj_8
Snippet: In a cohort of 237 allogeneic HCT recipients with RSV infection, the hazard ratio (HR) of experiencing progression from RSV URTI to LRTI was 4.1 for an absolute neutrophil count of <500 cells/mL and 2.6 for an absolute lymphocyte count of <200 cells/mL, 53 making them the most predictive factors for progression. 53 Among leukemia patients, post-induction chemotherapy neutropenia and leukopenia have also been shown to increase the risk of progress.....
Document: In a cohort of 237 allogeneic HCT recipients with RSV infection, the hazard ratio (HR) of experiencing progression from RSV URTI to LRTI was 4.1 for an absolute neutrophil count of <500 cells/mL and 2.6 for an absolute lymphocyte count of <200 cells/mL, 53 making them the most predictive factors for progression. 53 Among leukemia patients, post-induction chemotherapy neutropenia and leukopenia have also been shown to increase the risk of progression to LRTI. 22, 24 In a recent retrospective study, neutropenia and lymphopenia were not independently associated with progression of disease in HM patients, but the combination of the two factors was associated with a higher risk of progression. 37 However, time from last chemotherapy was not shown to play a role in progression to LRTI in HM patients. 37 On the other hand, lack of ribavirin therapy was associated with progression of dishaematologica | 2019; 104(7) 37, 53, 58 The protective benefits of ribavirin are discussed further in the treatment section.
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