RNA structure interactions and ribonucleoprotein processes of the influenza A virus

Dawson, Wayne K; Lazniewski, Michal; Plewczynski, Dariusz

The virions of the IAV are observed in both a spherical or filamentous shape [4, 53, 54] , where in both cases, only one copy of viral genomic appears to be present [54] ; the capsid is neither a random collection of vRNPs nor multiple copies of the genome. The virions in which '7 þ 1' clusters of vRNP where observed were all spherical [46, 55] . The filamentous structure can sometimes encompass same space as eight spherical virions [46] . One might assume that as the virion can fit in a sphere, it would be the most likely shape of the virus. However, the filamentous structure appears to be the more commonly observed form. It is not presently known exactly what determines whether the virion is spherical or filamentous nor is it Full-length structure. Inhibits the interferon-mediated antiviral response [38] . The NS1 protein of IAV serves a critical role in suppressing the production of host mRNAs by inhibiting the 3 0 -end processing of host pre-mRNAs and consequently blocking the production of host mRNAs, including interferon-b mRNAs. Also involved in the import of the viral RNPs, tends to help hijack the import mechanism using importin alpha [31] [32] [33] . NEP (formerly NS2) 98