Author: Dawson, Wayne K; Lazniewski, Michal; Plewczynski, Dariusz
Title: RNA structure interactions and ribonucleoprotein processes of the influenza A virus Document date: 2017_10_10
ID: 3opbf2cp_9
Snippet: An additional component of the vRNP is the viral polymerase. In Figure 1 (top panel, left-hand side), the viral polymerase is a hetrotrimer comprised the following proteins: polymerase acidic (PA; Segment 3), polymerase basic 1 (PB1; Segment 2) and polymerase basic 2 (PB2; Segment 1), with the polymerase located near the 5 0 -/3 0 -termini of the vRNA sequence [42] . It is important to note that [43] reports the location of the viral polymerase a.....
Document: An additional component of the vRNP is the viral polymerase. In Figure 1 (top panel, left-hand side), the viral polymerase is a hetrotrimer comprised the following proteins: polymerase acidic (PA; Segment 3), polymerase basic 1 (PB1; Segment 2) and polymerase basic 2 (PB2; Segment 1), with the polymerase located near the 5 0 -/3 0 -termini of the vRNA sequence [42] . It is important to note that [43] reports the location of the viral polymerase at the hairpin side (the exact opposite side of the 5 0 /3 0termini) of the ensiform structure, and the ds helix of NPs has a left-handed twist instead of a right-handed twist. Nevertheless, either way, the nucleocapsid proteins are PB1, PB2, PA and NP, where NP adopts a needle-shaped scaffold for the ssRNA and the viral polymerase is positioned at one end. The viral polymerase is essential for the transcription of the viral mRNA sequences and replication of the viral genome [44] .
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