Author: Rocio Bravo Jeria; Maria X Rojas Reyes; Juan V Franco; Maria P Acuna; Luz A Torres Lopez; Gabriel rada Rada
Title: Chloroquine and hydroxychloroquine for the treatment of COVID-19: A living systematic review protocol Document date: 2020_4_8
ID: fckn8ld4_4
Snippet: Notwithstanding, despite its in vitro activity against several agents, to this date there is no acute viral infection that has been successfully treated by chloroquine or hydroxychloroquine. Moreover, in Chikungunya virus infection, chloroquine showed the paradoxical effect of leading to more chronic complications in the patients who received it, an outcome that would be explained by a delay in immune adaptive response [13] . The pathogenesis of .....
Document: Notwithstanding, despite its in vitro activity against several agents, to this date there is no acute viral infection that has been successfully treated by chloroquine or hydroxychloroquine. Moreover, in Chikungunya virus infection, chloroquine showed the paradoxical effect of leading to more chronic complications in the patients who received it, an outcome that would be explained by a delay in immune adaptive response [13] . The pathogenesis of COVID-19 is still unknown, therefore the clinical effects of administration of antimalarials in COVID-19 patients is largely unpredictable [ 14 ] .
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