Title: Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon Document date: 1977_4_1
ID: 5v7k90zr_24
Snippet: To see if the antiviral activity of interferon could be dissociated from the factor responsible for enhancement of histamine release, interferon samples were treated by: (a) dialysis (pH 2.0 for 24 h); (b) heat (65°C for 30 min); or (c) trypsin (0.002% trypsin for 1 h at 37°C). The treated samples were then tested for their ability to enhance histamine release and for their antiviral activity. The data in Table IV show that trypsin destroyed bo.....
Document: To see if the antiviral activity of interferon could be dissociated from the factor responsible for enhancement of histamine release, interferon samples were treated by: (a) dialysis (pH 2.0 for 24 h); (b) heat (65°C for 30 min); or (c) trypsin (0.002% trypsin for 1 h at 37°C). The treated samples were then tested for their ability to enhance histamine release and for their antiviral activity. The data in Table IV show that trypsin destroyed both the antiviral and the histamineenhancing activity of the samples, while treatment with pH 2.0 or heat failed to destroy either activity.
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