Author: Baek, Hyekyung; Kim, Kwang Ho; Park, Min Young; Kim, Kyeongryun; Ko, Bokyeong; Seo, Hyung Seok; Kim, Byoung Soo; Hahn, Tae-Wook; Yi, Sun Shin
Title: Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines Document date: 2017_8_22
ID: 52sbckm3_28
Snippet: All bio-modulations in the human body are regulated and maintained mainly by the central nervous system, particularly, the brain. This important organ is defended by the protective BBB. The highly selective permeability of the BBB is very useful in preventing some macromolecules, toxic substances, and microorganisms from penetrating brain tissue from adjacent blood vessels [1, 22] . However, if the BBB is unexpectedly damaged or loses its protect.....
Document: All bio-modulations in the human body are regulated and maintained mainly by the central nervous system, particularly, the brain. This important organ is defended by the protective BBB. The highly selective permeability of the BBB is very useful in preventing some macromolecules, toxic substances, and microorganisms from penetrating brain tissue from adjacent blood vessels [1, 22] . However, if the BBB is unexpectedly damaged or loses its protective function following injection of a novel vaccine with insufficient safety verification, brain impairment and malfunction can result. Therefore, there is a necessity to develop an expeditious vaccine assessment module that would assure the BBB was secure.
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