Selected article for: "amino LBR terminal domain and LBR terminal domain"
Title: The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal
  • Document date: 1993_3_1
    • ID: 377v2ufn_37
    Snippet: In addition to the "classical" NLS found in SV-40 large T antigen, up to 40% of nuclear proteins use a second class of NLS exemplified by the bipartite NLS of nucleoplasmin (Robbins et al., 1991) . Two sequences in the amino-terminal domain of LBR (from Arg ~3 to Arg 7~ and from Arg 93 to Lys ~~ roughly fit the sequence of the nucleoplasmin-like bipartite motif that can function as an NLS (Robbins et al., 1991) . Therefore, the amino-terminal dom.....
    Document: In addition to the "classical" NLS found in SV-40 large T antigen, up to 40% of nuclear proteins use a second class of NLS exemplified by the bipartite NLS of nucleoplasmin (Robbins et al., 1991) . Two sequences in the amino-terminal domain of LBR (from Arg ~3 to Arg 7~ and from Arg 93 to Lys ~~ roughly fit the sequence of the nucleoplasmin-like bipartite motif that can function as an NLS (Robbins et al., 1991) . Therefore, the amino-terminal domain of LBR may use a nucleoplasmin-like bipartite NLS to enter the nucleus. Proteins that contain this type of NLS may use different cytoplasmic and nuclear pore complex receptor proteins and may not concentrate in the nucleolus during nuclear accumulation.

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