Author: Cross, Robert W.; Mire, Chad E.; Borisevich, Viktoriya; Geisbert, Joan B.; Fenton, Karla A.; Geisbert, Thomas W.
Title: The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for 3 Species of Ebolavirus Document date: 2016_8_15
ID: 6nu7rob8_3
Snippet: The domestic ferret (Mustela putorius furo) is an animal model for a variety of viral diseases, including rabies, influenza, severe acute respiratory syndrome, and for several medically important paramyxoviruses [5] . None of these ferret models require adaptation of the challenge virus to produce a lethal infection. Recent availability of an annotated genome for the ferret has suggested that the susceptibility it shares with humans to these infe.....
Document: The domestic ferret (Mustela putorius furo) is an animal model for a variety of viral diseases, including rabies, influenza, severe acute respiratory syndrome, and for several medically important paramyxoviruses [5] . None of these ferret models require adaptation of the challenge virus to produce a lethal infection. Recent availability of an annotated genome for the ferret has suggested that the susceptibility it shares with humans to these infections is potentially attributable to substantial homologies to many disease-relevant human proteins, including viral entry receptors [6] . Collectively, these data provided the rationale to assess the utility of the ferret as a model for Ebolavirus disease. Here, we performed a narrowly focused study to determine whether ferrets have the potential to serve as a small-animal model for 3 species of Ebolavirus.
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