Selected article for: "chain reaction and RT PCR chain reaction"

Author: MINAMI, Shohei; TERADA, Yutaka; SHIMODA, Hiroshi; TAKIZAWA, Masaki; ONUMA, Mamoru; OTA, Akihiko; OTA, Yuichi; AKABANE, Yoshihito; TAMUKAI, Kenichi; WATANABE, Keiichiro; NAGANUMA, Yumiko; KANAGAWA, Eiichi; NAKAMURA, Kaneichi; OHASHI, Masanari; TAKAMI, Yoshinori; MIWA, Yasutsugu; TANOUE, Tomoaki; OHWAKI, Masao; OHTA, Jouji; UNE, Yumi; MAEDA, Ken
Title: Establishment of serological test to detect antibody against ferret coronavirus
  • Document date: 2016_3_3
  • ID: 3g75spkc_2
    Snippet: Although FRcoV genes were detected in ferrets by reverse transcription-polymerase chain reaction (RT-PcR), there is no method to detect antibodies to FRcoV. We attempted to isolate FRcoV using feline cell lines and our newly established ferret cell line (manuscript in preparation), but the virus has not yet been isolated. Because the nucleocapsid (N) is conserved between coronaviruses and used as an antigen to detect antibody [5, 8] , the N prote.....
    Document: Although FRcoV genes were detected in ferrets by reverse transcription-polymerase chain reaction (RT-PcR), there is no method to detect antibodies to FRcoV. We attempted to isolate FRcoV using feline cell lines and our newly established ferret cell line (manuscript in preparation), but the virus has not yet been isolated. Because the nucleocapsid (N) is conserved between coronaviruses and used as an antigen to detect antibody [5, 8] , the N protein of FRcoV was one of the most likely antigen candidates to detect antibody to FRcoV. In this study, an enzyme-linked immunosorbent assay (ELISA) using recombinant N proteins was established and applied to investigate the seroprevalence of FRcoV infection in Japan.

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