Author: Mok, Hoyin; Cheng, Xing; Xu, Qi; Zengel, James R; Parhy, Bandita; Zhao, Jackie; Wang, C. Kathy; Jin, Hong
Title: Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350 Document date: 2012_2_16
ID: 3qdjmb2j_32
Snippet: Animal model is not available for assessing EBV vaccine induced protective immune response. Cotton rat is the best available small animal model to evaluate RSV vaccine induced protection against wt RSV challenge infection. To assess if the immune responses induced from sF1 and sF3 could provide protection against RSV A2 challenge, vaccinated cotton rats were challenged with RSV A2 intranasally and virus titers in the lungs were measured. Similar .....
Document: Animal model is not available for assessing EBV vaccine induced protective immune response. Cotton rat is the best available small animal model to evaluate RSV vaccine induced protection against wt RSV challenge infection. To assess if the immune responses induced from sF1 and sF3 could provide protection against RSV A2 challenge, vaccinated cotton rats were challenged with RSV A2 intranasally and virus titers in the lungs were measured. Similar to RSV infected animals, sF1 or sF3 offered complete protection against RSV A2 challenge with viral titers in the lungs that was at least 4.5 log 10 lower than the control animals. In contrast, cotton rats vaccinated with 10 5 PFU of UV-inactivated sF3 had viral titer similar to the PBS control group, indicating that viral replication is necessary for induction of protective immune response (Fig. 4) .
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