Author: Mok, Hoyin; Cheng, Xing; Xu, Qi; Zengel, James R; Parhy, Bandita; Zhao, Jackie; Wang, C. Kathy; Jin, Hong
Title: Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350 Document date: 2012_2_16
ID: 3qdjmb2j_37
Snippet: The cotton rats immunized with MV expressing RSV F were also challenged with wt RSV. After challenge, the number of IFN-secreting cells was higher than IL-4 secreting cells, which was consistent with a Th1-biased response (data not shown). RSV enhanced disease has been associated with FI-RSV vaccine [54, 55] . A chimeric parainfluenza virus vectored RSV F [35] did not cause enhanced disease in hamsters and has been proven to be safe in phase I cl.....
Document: The cotton rats immunized with MV expressing RSV F were also challenged with wt RSV. After challenge, the number of IFN-secreting cells was higher than IL-4 secreting cells, which was consistent with a Th1-biased response (data not shown). RSV enhanced disease has been associated with FI-RSV vaccine [54, 55] . A chimeric parainfluenza virus vectored RSV F [35] did not cause enhanced disease in hamsters and has been proven to be safe in phase I clinical trial in seronegative children [56] . Recently, a report from another group has shown that measles virus vectored RSV F did not cause unusual pathology in cotton rats after RSV challenge, thus, the likelihood of the MV vector F to cause enhanced disease is very low [15] .
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