Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting Document date: 2012_7_19
ID: 629fwmgk_19
Snippet: Overall, our observations suggest that older de novo genes are more adapted to their genome and evolve under stronger purifying selection. This inference is supported by experimental data on the fitness effects of mutations in de novo genes of different ages (table 3) . Mutations in the youngest de novo genes (taxa 1-3) have little to moderate effect, whereas FIG. 4 . Codon Similarity Index (CSI) of ancestral (red) and de novo genes (blue). The h.....
Document: Overall, our observations suggest that older de novo genes are more adapted to their genome and evolve under stronger purifying selection. This inference is supported by experimental data on the fitness effects of mutations in de novo genes of different ages (table 3) . Mutations in the youngest de novo genes (taxa 1-3) have little to moderate effect, whereas FIG. 4 . Codon Similarity Index (CSI) of ancestral (red) and de novo genes (blue). The horizontal axis represents the evolutionary distance from the origin of each de novo gene (as in fig. 3 ). Regression lines are plotted for visualization of general trends. High CSI values indicate high similarity between the codon usage of a gene and the codon usage of the rest of a genome. Colors are displayed in the electronic version of the paper. . Involved in regulation of polymerase activity (Mazur et al. 2008 ). Function seems strain-specific and host-specific and is disputed (Krumbholz et al. 2011) .
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