Author: Munday, Diane C.; Emmott, Edward; Surtees, Rebecca; Lardeau, Charles-Hugues; Wu, Weining; Duprex, W. Paul; Dove, Brian K.; Barr, John N.; Hiscox, Julian A.
Title: Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus Document date: 2010_7_20
ID: 2zhaknbi_61
Snippet: Potential Disruption of Nucleocytoplasmic Trafficking and Nuclear Pore Complex Proteins-In HRSV-infected cells, several proteins associated with nucleocytoplasmic trafficking and the nuclear pore complex were identified as altered, including nup96 and nup98. This could be a common feature of RNA virus infection (89) as other negative strand RNA viruses that replicate in the cytoplasm, such as vesicular stomatitis virus, have been shown to inhibit.....
Document: Potential Disruption of Nucleocytoplasmic Trafficking and Nuclear Pore Complex Proteins-In HRSV-infected cells, several proteins associated with nucleocytoplasmic trafficking and the nuclear pore complex were identified as altered, including nup96 and nup98. This could be a common feature of RNA virus infection (89) as other negative strand RNA viruses that replicate in the cytoplasm, such as vesicular stomatitis virus, have been shown to inhibit RAN-dependent trafficking (90) . Specifically, the virus-encoded matrix protein can inhibit nuclear import and export (91) . This virus has been shown to target nup96 and nup98 for degradation (92) , potentially to inhibit antiviral activity (93) . nup98 is an IFN-induced nuclear pore complex protein with a major role in the export of mRNA. The positive strand RNA viruses poliovirus and rhinovirus are also capable of inhibiting nucleocytoplasmic trafficking (94, 95) , and nup98 is degraded in rhinovirusinfected cells (96) .
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