Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_11_10
ID: 02pjdufw_18
Snippet: Random vaccination in a hypothetical population. To illustrate the potential impact of dose fractionation, we first consider a hypothetical scenario where the entire population is susceptible (S 0 = 1) and each individual has the same probability of receiving vaccination. We compare the outcome of using the entire vaccine stockpile for either standard-dose or five-fold fractional-dose vaccination. If some individuals are immune (S 0 < 1, due to p.....
Document: Random vaccination in a hypothetical population. To illustrate the potential impact of dose fractionation, we first consider a hypothetical scenario where the entire population is susceptible (S 0 = 1) and each individual has the same probability of receiving vaccination. We compare the outcome of using the entire vaccine stockpile for either standard-dose or five-fold fractional-dose vaccination. If some individuals are immune (S 0 < 1, due to previous exposure or vaccination) and vaccination can be targeted at susceptible individuals only, then the resulting IAR within the susceptible population would be the same as that for random vaccination in a completely susceptible population with coverage V / S 0 and basic reproductive number R 0 S 0 .
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