Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_11_10
ID: 02pjdufw_30
Snippet: Even more unlikely, in our opinion, is that fractionated doses would be substantially less efficacious according to a "leaky" model, in which all vaccinated individuals were imperfectly protected against infection from each infectious bite, with the same probability of infection from each bite, reduced by vaccine by a proportion VE (see appendix for details). If this were the case however, we found that especially in high-transmission areas, the .....
Document: Even more unlikely, in our opinion, is that fractionated doses would be substantially less efficacious according to a "leaky" model, in which all vaccinated individuals were imperfectly protected against infection from each infectious bite, with the same probability of infection from each bite, reduced by vaccine by a proportion VE (see appendix for details). If this were the case however, we found that especially in high-transmission areas, the fractionated-dose vaccine would need to be 80-90% efficacious to provide a benefit over standard dosing.
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