Generation and protective efficacy of a cold-adapted attenuated genotype 2b porcine epidemic diarrhea virus

Won, Hokeun; Lee, Dong-Uk; Jang, Guehwan; Noh, Yun-Hee; Lee, Seung-Chul; Choi, Hwan-Won; Yoon, In-Joong; Yoo, Han Sang; Lee, Changhee

PEDV causes acute gastrointestinal symptoms characterized by a rapid onset of severe watery diarrhea, vomiting, fatal dehydration, and high mortality in newborn and suckling piglets [7] . In 1971, the virus was initially recognized in England and had since been geographically restricted and problematic in Europe and Asia during the past four decades [8] . However, in early 2013, PEDV first emerged in the United States and rapidly spread to the adjacent North and South American countries, causing significant financial losses to their swine industries [9] [10] [11] . Soon after, the US prototype-like highly virulent G2b PEDV strains almost simultaneously invaded multiple Asian nations, including South Korea, Taiwan, and Japan, resulting in the recurrence of a massive nationwide PED epizootic [5, 12, 13] . PEDV has now emerged or re-emerged as one of the most devastating porcine viruses, posing a tremendous threat to the global pork business.