Author: Sakthivel, Muthukumar; Elkashif, Sami; Al Ansari, Khalid; Powell, Colin V.E.
Title: Rebound stridor in children with croup after nebulised adrenaline: does it really exist? Document date: 2019_3_23
ID: 5er37cdx_16
Snippet: Three small studies [17] [18] [19] , involving 48 children in total, showed significant initial improvement using nebulised adrenaline compared to placebo with some return of symptoms but no rebound reported. The following studies started using steroids in their design and recruited larger numbers but in children with more severe croup. No rebound of symptoms is described and an effect of the Children who received racemic adrenaline were signific.....
Document: Three small studies [17] [18] [19] , involving 48 children in total, showed significant initial improvement using nebulised adrenaline compared to placebo with some return of symptoms but no rebound reported. The following studies started using steroids in their design and recruited larger numbers but in children with more severe croup. No rebound of symptoms is described and an effect of the Children who received racemic adrenaline were significantly better than placebo in terms of improvement in total clinical score, inspiratory stridor, retractions and air entry. Relapse phenomenon was seen in 35% of children in the treatment group and 25% in placebo group.
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