Author: George, Melissa R
Title: Hemophagocytic lymphohistiocytosis: review of etiologies and management Document date: 2014_6_12
ID: 3frxd1c1_17
Snippet: Malignancies are associated with a significant percentage of secondary HLH cases (up to 27%). 35 Among these cases, hematologic malignancies are most prevalent. These hematologic disorders can be best classified according to cell type. In children, HLH is most commonly associated with acute B-lymphoblastic leukemia. 154 The cytokines released in malignancy, mainly IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α are believed to be the inciting factor.....
Document: Malignancies are associated with a significant percentage of secondary HLH cases (up to 27%). 35 Among these cases, hematologic malignancies are most prevalent. These hematologic disorders can be best classified according to cell type. In children, HLH is most commonly associated with acute B-lymphoblastic leukemia. 154 The cytokines released in malignancy, mainly IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α are believed to be the inciting factor for malignancy-associated HLH. An overview of malignancies associated with HLH is given in Table 6 .
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