Author: Yen, Wei-Chen; Wu, Yi-Hsuan; Wu, Chih-Ching; Lin, Hsin-Ru; Stern, Arnold; Chen, Shih-Hsiang; Shu, Jwu-Ching; Tsun-Yee Chiu, Daniel
Title: Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling Document date: 2019_11_2
ID: 6fw4thkq_43
Snippet: The phosphorylation of p38 at different time points upon inflammasome activation was decreased in G6PD-kd THP-1 cells compared to that in the control cells without a change in the phosphorylation levels of p65, ERK and JNK (Fig. 4A) . The quantitative intensity of p-p38 is shown in Fig. 4B . Control and G6PD-kd THP-1 cells treated with SB203580 (an inhibitor of p38 MAPK) resulted in p38 inhibition (Fig. 4C) . Cells were reacted with LPS, which re.....
Document: The phosphorylation of p38 at different time points upon inflammasome activation was decreased in G6PD-kd THP-1 cells compared to that in the control cells without a change in the phosphorylation levels of p65, ERK and JNK (Fig. 4A) . The quantitative intensity of p-p38 is shown in Fig. 4B . Control and G6PD-kd THP-1 cells treated with SB203580 (an inhibitor of p38 MAPK) resulted in p38 inhibition (Fig. 4C) . Cells were reacted with LPS, which resulted in impaired pro- IL-1β expression (Fig. 4D) . The quantitative intensity of p-p38 and pro-IL-1β is shown in Fig. 4E and F, respectively.
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