Author: Tuplin, A.; Evans, D. J.; Buckley, A.; Jones, I. M.; Gould, E. A.; Gritsun, T. S.
Title: Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus Document date: 2011_5_27
ID: 0aiaklrn_4
Snippet: The concept of promoter and enhancer function during replication has been introduced recently in relation to the flavivirus CREs (16) . The promoter has been identified as a complex of highly conserved interacting RNA structures recruited from the 5 0 -and 3 0 -UTR to assemble viral and cellular proteins into a functional RdRp complex. In evolutionary terms, the 3 0 -UTR of the TBFV group is formed by four conserved long imperfectly repeated sequ.....
Document: The concept of promoter and enhancer function during replication has been introduced recently in relation to the flavivirus CREs (16) . The promoter has been identified as a complex of highly conserved interacting RNA structures recruited from the 5 0 -and 3 0 -UTR to assemble viral and cellular proteins into a functional RdRp complex. In evolutionary terms, the 3 0 -UTR of the TBFV group is formed by four conserved long imperfectly repeated sequences (LSRs), genetic remnants of which are revealed in the MBFV, NKV and PABV groups (17) . It has been proposed that the 5 0 -UTR may have evolved from a trans-terminal duplication of the archival flavivirus 3 0 -UTR (16) .
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