Selected article for: "influenza virus and viral infection"
Author: Poltronieri, Palmiro; Sun, Binlian; Mallardo, Massimo
Title: RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load
  • Document date: 2015_10_23
    • ID: 259cspey_29
    Snippet: Influenza A virus replicates its genome in the nucleus and is exposed to the nuclear microRNA processing factors Drosha and DGCR8. At 8 hours after infection, 18-to 27-nt small viral leader RNAs (leRNAs) bearing a 5'-terminal triphosphate are produced from the 5' ends of all eight influenza virus genomic RNA (vRNA) segments [35] . The highlevel production of leRNAs may imply a role in the regulation of the switch from viral mRNA transcription to .....
    Document: Influenza A virus replicates its genome in the nucleus and is exposed to the nuclear microRNA processing factors Drosha and DGCR8. At 8 hours after infection, 18-to 27-nt small viral leader RNAs (leRNAs) bearing a 5'-terminal triphosphate are produced from the 5' ends of all eight influenza virus genomic RNA (vRNA) segments [35] . The highlevel production of leRNAs may imply a role in the regulation of the switch from viral mRNA transcription to genomic RNA synthesis.

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