Selected article for: "broad tropism and cell surface protein"

Author: Takada, Ayato
Title: Filovirus Tropism: Cellular Molecules for Viral Entry
  • Document date: 2012_2_6
  • ID: 0j3efvfe_13
    Snippet: Although filoviruses can replicate in various tissues and cell types, the molecular mechanisms of their broad tropism remain poorly understood (Figure 6) . By using an expression cloning strategy that has been used to identify several virus receptors, human folate receptor-α was first identified as a ubiquitous cellular cofactor that mediates infection by both MARV and ZEBOV (Chan et al., 2001) . This molecule is a glycosyl-phosphatidylinositoll.....
    Document: Although filoviruses can replicate in various tissues and cell types, the molecular mechanisms of their broad tropism remain poorly understood (Figure 6) . By using an expression cloning strategy that has been used to identify several virus receptors, human folate receptor-α was first identified as a ubiquitous cellular cofactor that mediates infection by both MARV and ZEBOV (Chan et al., 2001) . This molecule is a glycosyl-phosphatidylinositollinked protein expressed on the cell-surface. However, a human immunodeficiency virus pseudotyped with EBOV GP could not www.frontiersin.org

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