Selected article for: "carboxy terminal and card domain"
Author: Baum, Alina; García-Sastre, Adolfo
Title: Induction of type I interferon by RNA viruses: cellular receptors and their substrates
  • Document date: 2009_11_1
    • ID: 4c1nuv2p_38
    Snippet: The third member of the RLR family, LGP2, has been implicated as a negative regulator of RIG-I and a positive regulator of MDA; however, the exact role of this molecule in viral infection remains controversial. Like RIG-I and MDA5, LGP2 contains a DExH/D box helicase domain and a carboxy-terminal RD. However, unlike those receptors, it lacks the CARD domain, and therefore, it is unable to signal through MAVS. Initial studies of LGP2 function demo.....
    Document: The third member of the RLR family, LGP2, has been implicated as a negative regulator of RIG-I and a positive regulator of MDA; however, the exact role of this molecule in viral infection remains controversial. Like RIG-I and MDA5, LGP2 contains a DExH/D box helicase domain and a carboxy-terminal RD. However, unlike those receptors, it lacks the CARD domain, and therefore, it is unable to signal through MAVS. Initial studies of LGP2 function demonstrated that upon overexpression this molecule had a negative effect on IFN production following Sendai virus or NDV infection, or poly(I:C) transfection.

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