Selected article for: "influenza virus and study influenza virus"
Author: Darwish, Ilyse; Miller, Chris; Kain, Kevin C.; Liles, W. Conrad
Title: Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza
  • Document date: 2012_1_13
    • ID: 1rktb6yq_16
    Snippet: In conclusion, despite the demonstrated antimicrobial activity of NO against influenza A virus in vitro, the results of this study do not support the use of iNO as a prophylactic or treatment strategy to reduce viral burden or improve clinical outcome in severe influenza in vivo. Furthermore, it may be difficult to achieve viricidal concentrations of NO in the airways using iNO at concentrations that are safe in the living host......
    Document: In conclusion, despite the demonstrated antimicrobial activity of NO against influenza A virus in vitro, the results of this study do not support the use of iNO as a prophylactic or treatment strategy to reduce viral burden or improve clinical outcome in severe influenza in vivo. Furthermore, it may be difficult to achieve viricidal concentrations of NO in the airways using iNO at concentrations that are safe in the living host.

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