ISG20 promotes local tumor immunity and contributes to poor survival in human glioma

Gao, Mengqi; Lin, Yi; Liu, Xing; Li, Yiming; Zhang, Chuanbao; Wang, Zheng; Wang, Zhiliang; Wang, Yulin; Guo, Zongze

The CGGA (http://www.cgga.org.cn) and TCGA (http://can cergenome.nih.gov) datasets were downloaded online. The transcriptome expression data of 932 gliomas were collected, ranging from WHO grade II to grade IV. In the CGGA dataset, there were 325 samples, including 144 GBM and 181 LGG samples. 63 In the TCGA dataset, 150 GBM and 457 LGG samples were available. Information on age, gender, diagnosis, WHO grade, chemo-and radiation therapy regimen, molecular data, and patient prognoses was also collected. Tumor tissues were also collected from 43 glioma patients who underwent surgery at the First Hospital of China Medical University between 2017 and 2018, including 19 WHO grade II patients, 12 grade III patients, and 12 GBM patients (Table S5 ). This study was approved by the ethics committee of the First Hospital of China Medical University, the institutional review boards of Capital Medical University, and the Beijing Institute for Brain Disorders Brain Tumor Center. Written informed consent was obtained from all patients.