Author: Vergara-Alert, Júlia; Vidal, Enric; Bensaid, Albert; Segalés, Joaquim
Title: Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS) coronavirus Document date: 2017_3_3
ID: 28vx9w58_23
Snippet: Type I pneumocytes and alveolar macrophages [24] Abbreviations: NHP, non-human primates; URT, upper respiratory tract. a Also animal models of disease (translation to human). and correlated with moderate to severe bronchointerstitial pneumonia. MERS-CoV antigen was detected by immunohistochemistry in both type I and II pneumocytes and alveolar macrophages, but the virus replicated only in type I pneumocytes and macrophages. Similar results were o.....
Document: Type I pneumocytes and alveolar macrophages [24] Abbreviations: NHP, non-human primates; URT, upper respiratory tract. a Also animal models of disease (translation to human). and correlated with moderate to severe bronchointerstitial pneumonia. MERS-CoV antigen was detected by immunohistochemistry in both type I and II pneumocytes and alveolar macrophages, but the virus replicated only in type I pneumocytes and macrophages. Similar results were observed in marmosets after inoculation of MERS-CoV only via intratracheal route [55] . However, the outcome of MERS-CoV infection in marmosets has been controversial after the publication of a recent study by Johnson and collaborators, which demonstrated no lethality after intratracheal inoculation [56] . The outcome of experimental infections in both species is reviewed in recent publications [17] [18] [19] [20] .
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